Paternal Age Alters Social Development in Offspring
نویسندگان
چکیده
منابع مشابه
Paternal Age Alters Social Development in Offspring
OBJECTIVE Advanced paternal age (APA) at conception has been linked with autism and schizophrenia in offspring, neurodevelopmental disorders that affect social functioning. The current study explored the effects of paternal age on social development in the general population. METHOD We used multilevel growth modeling to investigate APA effects on socioemotional development from early childhoo...
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Paternal environmental conditions can influence phenotypes in future generations, but it is unclear whether offspring phenotypes represent specific responses to particular aspects of the paternal exposure history, or a generic response to paternal 'quality of life'. Here, we establish a paternal effect model based on nicotine exposure in mice, enabling pharmacological interrogation of the speci...
متن کاملEffects of advanced paternal age on trajectories of social behavior in offspring.
Our study is the first investigation of the effects of advanced paternal age (APA) on the developmental trajectory of social behavior in rodent offspring. Given the strong epidemiological association between APA and sexually dimorphic neurodevelopmental disorders that are characterized by abnormalities in social behavior (autism, schizophrenia), we assessed sociability in male and female inbred...
متن کاملAdvanced paternal age increases risk of bipolar disorder in offspring.
ED FROM Frans EM, Sandin S, Reichenberg A, et al. Advancing paternal age and bipolar disorder. Arch Gen Psychiatry 2008;65:1034–40. Correspondence to: Emma M Frans, MMedSc, Department of Medical Epidemiology and Biostatistics, Karolinksa Institute, PO Box 281, SE-171 77 Stockholm, Sweden; [email protected] Source of funding: None reported. c A table is published online only at http://ebmh.bmj.co...
متن کاملPaternal age predicts offspring chances of marriage and reproduction.
OBJECTIVES Mutation-selection balance theory proposes that a balance of forces between constantly arising mildly harmful mutations and selection causes variation in genetic configuration and phenotypic condition. As mutations are predominantly deleterious, the entry of variation due to mutations is kept at low frequencies by selection. It has recently been demonstrated that nearly all de novo m...
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ژورنال
عنوان ژورنال: Journal of the American Academy of Child & Adolescent Psychiatry
سال: 2017
ISSN: 0890-8567
DOI: 10.1016/j.jaac.2017.02.006